FITC标记的溶质载体蛋白家族20成员2抗体
产品名称： FITC标记的溶质载体蛋白家族20成员2抗体
英文名称： Anti-SLC20A2/FITC
产品编号： HZ-8610R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SLC20A2/FITC Conjugated antibody
FITC标记的溶质载体蛋白家族20成员2抗体
| 英文名称 | Anti-SLC20A2/FITC |
| 中文名称 | FITC标记的溶质载体蛋白家族20成员2抗体 |
| 别 名 | Gibbon ape leukemia virus receptor 2; Gibbon leukemia virus receptor 2; GLVR 2; GLVR-2; GLVR2; hPit2; IBGC3; MLVAR; Murine leukemia virus amphotropic receptor; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PIT 2; PiT-2; Pit2; RAM1; S20A2_HUMAN; SLC20A2; Sodium-dependent phosphate transporter 2; Solute carrier family 20 (phosphate transporter) member 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 细菌及病毒 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC20A2/PIT2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The SLC20 family transport proteins were originally identified as retroviral receptors Glvr-1 and Ram-1, but are now designated sodium-dependent phosphate transporters 1 and 2 (PiT1 and PiT2). The PiT proteins function as sodium-phosphate cotransporters and are widely expressed, with high expression in bone, kidney and intestine. Both PiT1 and PiT2 are expressed on polarized epithelial cell membranes where they play a role in cellular phosphate homeostasis. PiT2 is a human receptor for amphotropic murine leukemia virus (A-MuLV). A-MuLV infects a variety of mammalian cell lines, including humans, making it a useful tool in gene transfer technology and as a vector for gene therapy. Retroviral vector systems are used in gene therapy that are designed to infect cells expressing PiT1 or PiT2. Function: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. Subunit: Homodimer. Subcellular Location: Cell membrane. Tissue Specificity: Ubiquitously expressed. DISEASE: Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3) [MIM:614540]. An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. Similarity: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Database links: Entrez Gene: 6575 Human Entrez Gene: 20516 Mouse Entrez Gene: 29502 Rat Omim: 158378 Human SwissProt: Q95L97 Cat SwissProt: Q08357 Human SwissProt: Q80UP8 Mouse SwissProt: Q63488 Rat Unigene: 653173 Human Unigene: 323901 Mouse Unigene: 378231 Mouse Unigene: 13642 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SLC20家族转运蛋白最初被鉴定为逆转录病毒受体Glvr-1和Ram-1，但现在被指定为钠依赖性磷酸盐转运蛋白1和2(PiT1和PiT2)。PiT蛋白作为磷酸钠共转运蛋白广泛表达于骨骼、肾脏和肠道。PIT1和PIT2都在极化上皮细胞膜上表达，它们在细胞磷酸稳态中起作用。PIT2是嗜异性鼠白血病病毒（A－Mulv）的人受体。A-MuLV感染包括人类在内的多种哺乳动物细胞系，使其成为基因转移技术中有用的工具和基因治疗载体。逆转录病毒载体系统用于基因治疗，其目的是感染表达PIT1或PIT2的细胞。