FITC标记的G蛋白通路抑制物蛋白2抗体
产品名称： FITC标记的G蛋白通路抑制物蛋白2抗体
英文名称： Anti-GPS2/FITC
产品编号： HZ-15395R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPS2/FITC Conjugated antibody
FITC标记的G蛋白通路抑制物蛋白2抗体
| 英文名称 | Anti-GPS2/FITC |
| 中文名称 | FITC标记的G蛋白通路抑制物蛋白2抗体 |
| 别 名 | AMF-1; G protein pathway suppressor 2; GPS-2; GPS2; MGC104294; MGC119287; MGC119288; MGC119289; GPS2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 染色质和核信号 信号转导 G蛋白偶联受体 表观遗传学 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPS2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008] Function: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Tissue Specificity: Widely expressed. Database links: Entrez Gene: 2874 Human SwissProt: Q13227 Human Unigene: 438219 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码涉及G蛋白丝裂原活化蛋白激酶（MAPK）信号级联的蛋白质。当在哺乳动物细胞中过量表达时，该基因能够有效地抑制RAS和MAPK介导的信号并干扰JNK活性，提示该基因的功能可能是信号抑制。该编码蛋白是NCOR1-HDAC3(核受体辅阻遏物1-组蛋白脱乙酰酶3)复合物的一个完整亚基，并且表明该复合物通过该亚基抑制JNK的激活，因此可能为激素介导的拮抗抗神经胶质瘤提供替代机制。AP1（激活蛋白1）功能。[ RefSeq，JUL 2008 ]