FITC标记的神经元突触前膜蛋白抗体
产品名称： FITC标记的神经元突触前膜蛋白抗体
英文名称： Anti-Amphiphysin/FITC
产品编号： HZ-2409R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Amphiphysin/FITC Conjugated antibody
FITC标记的神经元突触前膜蛋白抗体
| 英文名称 | Anti-Amphiphysin/FITC |
| 中文名称 | FITC标记的神经元突触前膜蛋白抗体 |
| 别 名 | Amphiphysin; Amp; AMPH 1; AMPH1; Amphiphysin (Stiff-Man syndrome with breast cancer 128kD autoantigen); Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen); Amphiphysin I; CG8604; Damp; dAmph; Dmel\CG8604; HGNC:471; MGC49429; Stiff man syndrome with breast cancer 128kD autoantigen; Stiff man syndrome with breast cancer 128kDa autoantigen; AMPH_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Amphiphysin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Amphiphysin is associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants (Amphiphysin 1 and Amphiphysin 2) encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. Function: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. Subunit: Heterodimer with BIN1. Binds SH3GLB1 and AP2A2. Interacts with AP2B1. Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Tissue Specificity: Neurons, certain endocrine cell types and spermatocytes. Similarity: Contains 1 BAR domain. Contains 1 SH3 domain. Database links: Entrez Gene: 273 Human Entrez Gene: 218038 Mouse Entrez Gene: 60668 Rat Omim: 600418 Human SwissProt: P49418 Human SwissProt: Q7TQF7 Mouse SwissProt: O08838 Rat Unigene: 592182 Human Unigene: 101650 Mouse Unigene: 44463 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
双亲素与突触小泡的细胞质表面有关。患有乳腺癌的僵硬综合征患者的一个子集对自身抗体是阳性的。该基因的交替剪接导致编码不同亚型的两个转录变体（两亲素1和两亲素2）。已经描述了附加剪接变异体，但它们的全长序列尚未确定。