FITC标记的环指蛋白24抗体
产品名称： FITC标记的环指蛋白24抗体
英文名称： Anti-RNF24/FITC
产品编号： HZ-9239R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RNF24/FITC Conjugated antibody
FITC标记的环指蛋白24抗体
| 产品编号 | bs-9239R-FITC |
| 英文名称 | Anti-RNF24/FITC |
| 中文名称 | FITC标记的环指蛋白24抗体 |
| 别 名 | G1L; Goliath-like protein (C3HC4 type); RING finger protein 24; Rnf24; RNF24_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF24 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF24 (ring finger protein 24), also known as Goliath-like protein (C3CH4 type) or G1L, is a single-pass membrane protein found in the Golgi apparatus, consisting of 148 amino acids. RNF24 causes intracellular retention of TRPCs, regulates insertion of TRPCs into the plasma membrane and interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. The RNF24 protein shares similarity with Drosophila Goliath protein and thus, may function as a transcription factor. Multiple transcript variants encoding different isoforms have been found for the RNF24 gene, which maps to human chromosome 20p13. Function: May play a role in TRPCs intracellular trafficking. Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Subcellular Location: Golgi apparatus membrane; Single-pass membrane protein. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 11237 Human SwissProt: Q9Y225 Human SwissProt: Q9Y225-2 Human Unigene: 589884 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
环型锌指基序存在于许多病毒和真核蛋白质中，并且由能够结合两个锌原子的保守的富含半胱氨酸的结构域构成。含有保守结构域的蛋白质一般参与蛋白质降解的泛素化途径。RNF24（环指蛋白24），又称Galia-样蛋白（C3CH4型）或G1L，是在高尔基体中发现的单遍膜蛋白，由148个氨基酸组成。RNF24引起TrPCs的细胞内滞留，调节TrPCs插入到质膜中，并与TrPC1、TrPC3、TrPC4、TrPC5、TrPC6和TrPC7相互作用。RNF24蛋白与果蝇Galias蛋白具有相似性，因此可以作为转录因子发挥作用。RNF24基因的多个转录变体编码不同的亚型，该基因定位于人类染色体20p13。