CBFB polyclonal antibody (A01)
产品名称： CBFB polyclonal antibody (A01)
英文名称： CBFB polyclonal antibody (A01)
产品编号： H00000865-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant CBFB.
- Immunogen:
- CBFB (NP_001746, 74 a.a. ~ 163 a.a) partial recombinant protein with GST tag.
- Sequence:
- QGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREE
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.01 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- CBFB polyclonal antibody (A01), Lot # 050928JC01 Western Blot analysis of CBFB expression in Jurkat ( Cat # L017V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 865
- GeneBank Accession#:
- NM_001755
- Protein Accession#:
- NP_001746
- Gene Name:
- CBFB
- Gene Alias:
- PEBP2B
- Gene Description:
- core-binding factor, beta subunit
- Omim ID:
- 121360
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- SL3-3 enhancer factor 1 beta subunit,SL3/AKV core-binding factor beta subunit,polyomavirus enhancer binding protein 2, beta subunit