FITC标记的软骨基质相关蛋白UCMA抗体
产品名称： FITC标记的软骨基质相关蛋白UCMA抗体
英文名称： Anti-UCMA/FITC
产品编号： HZ-12378R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-UCMA/FITC Conjugated antibody
FITC标记的软骨基质相关蛋白UCMA抗体
| 英文名称 | Anti-UCMA/FITC |
| 中文名称 | FITC标记的软骨基质相关蛋白UCMA抗体 |
| 别 名 | C10orf49; Gla rich protein; Gla-rich protein; Grp; GRP; OTTMUSP00000011599; RP23-272I15.1; UCMA; Ucma-C; UCMA_HUMAN; Unique cartilage matrix associated protein; Unique cartilage matrix-associated protein C-terminal fragment; Upper zone of growth plate and cartilage matrix associated. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UCMA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage. Function: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Subcellular Location: Secreted > extracellular space > extracellular matrix. Tissue Specificity: Predominantly expressed in resting chondrocytes. Post-translational modifications: Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation. Sulfated on tyrosine residues. Similarity: Belongs to the UCMA family. Database links: UniProtKB/Swiss-Prot: Q8WVF2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UCMA是一种138氨基酸分泌蛋白，在长骨发育过程中在静止的软骨细胞中高度表达，被认为在软骨细胞分化的早期阶段起作用。一种呋喃类蛋白酶将UCMA加工成N末端37个氨基酸肽和C末端74个氨基酸肽，称为独特的软骨基质相关蛋白C末端片段(Ucma-C)。引入重组Ucma-C干扰间充质干细胞、MC3T3-E1前成骨细胞和原代成骨细胞的成骨分化。提示Ucma可能参与了软骨-骨界面和胎儿软骨周边区骨软骨前体细胞成骨分化的负调控。