XBP1 MaxPab rabbit polyclonal antibody (D01)
产品名称： XBP1 MaxPab rabbit polyclonal antibody (D01)
英文名称： XBP1 MaxPab rabbit polyclonal antibody (D01)
产品编号： H00007494-D01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against a full-length human XBP1 protein.
- Immunogen:
- XBP1 (NP_005071.2, 1 a.a. ~ 261 a.a) full-length human protein.
- Sequence:
- MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQLSPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVPYQPPFLCQWGRHQPSWKPLMN
- Host:
- Rabbit
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of XBP1 expression in transfected 293T cell line (H00007494-T02) by XBP1 MaxPab polyclonal antibody.
Lane 1: XBP1 transfected lysate(28.70 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Immunoprecipitation
- Immunoprecipitation of XBP1 transfected lysate using anti-XBP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with XBP1 purified MaxPab mouse polyclonal antibody (B01P) (H00007494-B01P).
- Protocol Download
- Entrez GeneID:
- 7494
- GeneBank Accession#:
- NM_005080.2
- Protein Accession#:
- NP_005071.2
- Gene Name:
- XBP1
- Gene Alias:
- TREB5,XBP2
- Gene Description:
- X-box binding protein 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq
- Other Designations:
- OTTHUMP00000028682,X-box-binding protein-1
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