FITC标记的氨基酸转运蛋白2抗体
产品名称： FITC标记的氨基酸转运蛋白2抗体
英文名称： Anti-SLC38A2/FITC
产品编号： HZ-12125R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SLC38A2/FITC Conjugated antibody
FITC标记的氨基酸转运蛋白2抗体
| 英文名称 | Anti-SLC38A2/FITC |
| 中文名称 | FITC标记的氨基酸转运蛋白2抗体 |
| 别 名 | Amino acid transporter 2; Amino acid transporter A2; ATA2; SNAT2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC38A2/SNAT2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. SNAT2, also designated ATA2, PRO1068 and SAT2 is encoded by the human gene SLC38A2. The functional role of SNAT2 in the nervous system is unclear. Protein expression is notably enriched in the spinal cord and brain stem nuclei of the auditory system. System A transport proteins are also present in placental tissue. These SNAT proteins may play a significant role in fetal development and inhibition of the transport system has been associated with fetal growth retardation. Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Subcellular Location: Cell membrane. Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. Tissue Specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). Post-translational modifications: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. Similarity: Belongs to the amino acid/polyamine transporter 2 family. Database links: Entrez Gene: 338044 Cow Entrez Gene: 54407 Human Entrez Gene: 67760 Mouse Entrez Gene: 29642 Rat Omim: 605180 Human SwissProt: Q96QD8 Human SwissProt: Q8CFE6 Mouse SwissProt: Q9JHE5 Rat Unigene: 221847 Human Unigene: 46754 Mouse Unigene: 16393 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SLC38基因家族的钠偶联中性氨基酸转运体(SNAT)包括系统A亚型SNAT1、SNAT2和SNAT4以及系统N亚型SNAT3和SNAT5。SLC38转运体对营养素的吸收、能量产生、新陈代谢、解毒和神经递质的循环是必不可少的。SnAT2，也被命名为ATA2，PRO1068和SAT2由人类基因SLC38 A2编码。SnAT2在神经系统中的功能作用尚不清楚。蛋白表达明显富集于听觉系统的脊髓和脑干核。系统A转运蛋白也存在于胎盘组织中。这些SNAT蛋白可能在胎儿发育中起重要作用，并且转运系统的抑制与胎儿生长迟缓有关。