FITC标记的组织相容性抗原DP抗体
产品名称： FITC标记的组织相容性抗原DP抗体
英文名称： Anti-HLA DP/FITC
产品编号： HZ-17541R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HLA DP/FITC Conjugated antibody
FITC标记的组织相容性抗原DP抗体
| 英文名称 | Anti-HLA DP/FITC |
| 中文名称 | FITC标记的组织相容性抗原DP抗体 |
| 别 名 | DP(W3); DP(W4); HLA class II histocompatibility antigen DP alpha 1 chain; HLA class II histocompatibility antigen DP alpha chain; HLA DP1A; HLA DPA 1; HLA SB alpha chain; HLADP; HLADPA1; HLASB; HLASB histocompatibility type; Human MHC class II HLA SB alpha gene; Major histocompatibility complex class II DP alpha 1; MHC class II antigen; MHC class II DP3 alpha; MHC class II DPA1; MHC class II HLA DPA1 antigen; PLT1; Primed lymphocyte test 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HLA DP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] Function: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a vital role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells and macrophages). Within the DP molecule the alpha and beta chain contain the polymorphisms governing the peptide binding specificities, resulting in up to 4 different molecules. Subcellular Location: Type I membrane protein. Database links: Entrez Gene: 3113 Human Omim: 142880 Human SwissProt: P20036 Human Unigene: 347270 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HLA-DPA1属于HLAⅡ类α链链。这类II分子是由α（DPA）和β（DPB）链组成的异源二聚体，它们都锚定在膜中。它通过呈现来自胞外蛋白的肽在免疫系统中发挥中心作用。II类分子在抗原呈递细胞（APC:B淋巴细胞、树突状细胞、巨噬细胞）中表达。α链约33-35kDa，其基因含有5个外显子。外显子1编码前导肽，外显子2和3编码两个细胞外结构域，外显子4编码跨膜结构域和细胞质尾部。在DP分子内，α链和β链都包含指定肽结合特异性的多态性，导致多达4个不同的分子。[ RefSeq，JUL 2008 ]