RARA (Human) Recombinant Protein (P01)
产品名称： RARA (Human) Recombinant Protein (P01)
英文名称： RARA (Human) Recombinant Protein (P01)
产品编号： H00005914-P01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Human RARA full-length ORF ( AAH08727, 1 a.a. - 462 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
- Theoretical MW (kDa):
- 76.56
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Publication Reference
- 1.
- Leucine-rich repeat kinase 2 modulates retinoic Acid-induced neuronal differentiation of murine embryonic stem cells.
Schulz C, Paus M, Frey K, Schmid R, Kohl Z, Mennerich D, Winkler J, Gillardon F.PLoS One. 2011;6(6):e20820. Epub 2011 Jun 9.
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 5914
- GeneBank Accession#:
- BC008727
- Protein Accession#:
- AAH08727
- Gene Name:
- RARA
- Gene Alias:
- NR1B1,RAR
- Gene Description:
- retinoic acid receptor, alpha
- Omim ID:
- 180240
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000164454,OTTHUMP00000164456,Retinoic acid receptor, alpha polypeptide,nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
- Gene Pathway
- Related Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Bipolar Disorder
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Drug Toxicity
- Edema
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Liver Cirrhosis
- Mental Disorders
- Metabolic Syndrome X