DNM1L monoclonal antibody (M01), clone 3B5
产品名称： DNM1L monoclonal antibody (M01), clone 3B5
英文名称： DNM1L monoclonal antibody (M01), clone 3B5
产品编号： H00010059-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a full length recombinant DNM1L.
- Immunogen:
- DNM1L (AAH24590.1, 1 a.a. ~ 710 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2b kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (103.84 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons.
Kim B, McLean LL, Philip SS, Feldman EL.Endocrinology. 2011 Oct;152(10):3638-47. Epub 2011 Aug 2.
- 2.
- Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy.
Vincent AM, Edwards JL, McLean LL, Hong Y, Cerri F, Lopez I, Quattrini A, Feldman EL.Acta Neuropathol. 2010 May 15. [Epub ahead of print]
- 3.
- Diabetes regulates mitochondrial biogenesis and fission in mouse neurons.
Edwards JL, Quattrini A, Lentz SI, Figueroa-Romero C, Cerri F, Backus C, Hong Y, Feldman EL.Diabetologia. 2009 Oct 22. [Epub ahead of print]
- 4.
- SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.
Figueroa-Romero C, Iniguez-Lluh JA, Stadler J, Chang CR, Arnoult D, Keller PJ, Hong Y, Blackstone C, Feldman EL.FASEB J. 2009 Jul 28. [Epub ahead of print]
- Applications
- Western Blot (Cell lysate)
- DNM1L monoclonal antibody (M01), clone 3B5 Western Blot analysis of DNM1L expression in K-562 ( Cat # L009V1 ).
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of DNM1L expression in transfected 293T cell line by DNM1L monoclonal antibody (M01), clone 3B5.
Lane 1: DNM1L transfected lysate(79 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to DNM1L on formalin-fixed paraffin-embedded human leiomyosarcoma tissue. [antibody concentration 1 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged DNM1L is approximately 0.3ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 10059
- GeneBank Accession#:
- BC024590
- Protein Accession#:
- AAH24590.1
- Gene Name:
- DNM1L
- Gene Alias:
- DLP1,DRP1,DVLP,DYMPLE,DYNIV-11,FLJ41912,HDYNIV,VPS1
- Gene Description:
- dynamin 1-like
- Omim ID:
- 603850
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq
- Other Designations:
- Dnm1p/Vps1p-like protein,dynamin 1-like protein,dynamin family member proline-rich carboxyl-terminal domain less,dynamin-like protein 4,dynamin-like protein IV,dynamin-related protein 1
- Gene Pathway
- Related Disease