FITC标记的Lhx4蛋白抗体
产品名称： FITC标记的Lhx4蛋白抗体
英文名称： Anti-Lhx4/FITC
产品编号： HZ-11880R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Lhx4/FITC Conjugated antibody
FITC标记的Lhx4蛋白抗体
| 英文名称 | Anti-Lhx4/FITC |
| 中文名称 | FITC标记的Lhx4蛋白抗体 |
| 别 名 | Gsh 4; Gsh4; Lhx4; LHX4_HUMAN; LIM Homeobox 4; LIM homeobox protein 4; LIM/homeobox protein Lhx4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Lhx4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The LIM domain (a zinc finger structure) is a protein-protein interaction motif found in several protein types, including homeodomain transcription factors and kinases, which has a role in many cellular processes. The LIM family of homeodomain proteins plays a role in organismal differentiation and development. Specifically, LHX4 and closely related LHX3 play essential roles in multiple developmental stages of the pituitary gland in mice. The LHX4 gene is expressed in murine fetal brain, spinal cord and cerebral cortex. In addition, LHX4 is expressed in the cerebral cortex and in the motor neurons of the CNS in adult rodents. A specific murine LHX4 gene mutation results in a short stature phenotype, pituitary and cerebelllar defects and sella turcica malformations. The LHX4 gene may be implicated in the t(1;4)(q25;q32) chromosomal translocation, which is associated with acute lymphoblastic leukemia. The LHX4 gene is also expressed in leukemic cells and may activate leukemogenesis. The human LHX4 gene maps to chromosome 1q25 and encodes a 390 amino acid protein. Function: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Subcellular Location: Nucleus. DISEASE: Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4) [MIM:262700]; also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: UniProtKB/Swiss-Prot: Q969G2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LIM结构域(锌指结构)是在多种蛋白质类型中发现的蛋白质-蛋白质相互作用基序，包括同源域转录因子和激酶，在许多细胞过程中起作用。利姆家族同源结构域蛋白在生物体分化和发育中起着重要的作用。具体而言，LHX4和密切相关的LHX3在小鼠垂体的多个发育阶段起着至关重要的作用。LHX4基因在小鼠胎脑、脊髓和大脑皮质中表达。此外，LHX4在成年啮齿类动物的大脑皮层和中枢神经系统的运动神经元中表达。小鼠LHX4基因突变导致身材矮小、脑垂体和小脑缺损以及鞍区畸形。LHX4基因可能与t(1;4)(q25;q32)染色体易位有关，与急性淋巴细胞白血病有关。LHX4基因也在白血病细胞中表达，并可能激活白血病发生。人类LHX4基因定位于染色体1q25，编码390个氨基酸蛋白。