GABBR1 Pre-design Chimera RNAi
产品名称： GABBR1 Pre-design Chimera RNAi
英文名称： GABBR1 Pre-design Chimera RNAi
产品编号： H00002550-R06
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_021903
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 2550
- Gene Name:
- GABBR1
- Gene Alias:
- FLJ92613,GABAB(1e),GABABR1,GABBR1-3,GPRC3A,dJ271M21.1.1,dJ271M21.1.2,hGB1a
- Gene Description:
- gamma-aminobutyric acid (GABA) B receptor, 1
- Omim ID:
- 603540
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq
- Other Designations:
- GABA-B receptor,GABAB, subunit 1c,OTTHUMP00000029114,OTTHUMP00000029115,OTTHUMP00000029116,OTTHUMP00000109099,gamma-aminobutyric acid (GABA) B receptor 1,seven transmembrane helix receptor
- Gene Pathway
- Related Disease
- Anorexia Nervosa
- Bulimia
- Carcinoma
- Epilepsy
- Epilepsy
- Epilepsy, Absence
- Epilepsy, Temporal Lobe
- Genetic Predisposition to Disease
- Lupus Erythematosus, Systemic
- Mental Disorders
- Multiple Sclerosis
- Narcolepsy
- Narcolepsy
- Nasopharyngeal Neoplasms
- Psychiatric Status Rating Scales
- Schizophrenia
- Schizophrenia
- Schizophrenic Psychology
- Sclerosis