CFB monoclonal antibody, clone 28A3
产品名称： CFB monoclonal antibody, clone 28A3
英文名称： CFB monoclonal antibody, clone 28A3
产品编号： MAB0781
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CFB.
- Immunogen:
- Native purified human CFB.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Complement factor B gene regulation: synergistic effects of TNF-alpha and IFN-gamma in macrophages.
Huang Y, Krein PM, Muruve DA, Winston BW.J Immunol. 2002 Sep 1;169(5):2627-35.
- 2.
- Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding.
Xu Y, Circolo A, Jing H, Wang Y, Narayana SV, Volanakis JE.J Biol Chem. 2000 Jan 7;275(1):378-85.
- 3.
- A conserved element in the serine protease domain of complement factor B.
Hourcade DE, Mitchell LM, Oglesby TJ.J Biol Chem. 1998 Oct 2;273(40):25996-6000.
- Entrez GeneID:
- 629
- Gene Name:
- CFB
- Gene Alias:
- BF,BFD,CFAB,FB,FBI12,GBG,H2-Bf,PBF2
- Gene Description:
- complement factor B
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq
- Other Designations:
- B-factor, properdin,C3 proaccelerator,C3 proactivator,C3/C5 convertase,OTTHUMP00000029283,OTTHUMP00000174690,glycine-rich beta-glycoprotein
- Gene Pathway
- Related Disease
- Abortion, Spontaneous
- Alzheimer Disease
- Alzheimer disease
- Ataxia Telangiectasia
- Ataxia telangiectasia
- Birth Weight
- Cardiovascular Diseases
- Choroid Diseases
- Choroidal Neovascularization
- Choroiditis
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression
- Diseases in Twins
- Edema
- Genetic Predisposition to Disease
- Glioblastoma